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Direct α-Functionalization of Simple Aldehydes via Oxidative N-Heterocyclic Carbene Catalysis

✍ Scribed by Mo, Junming; Yang, Ruojie; Chen, Xingkuan; Tiwari, Bhoopendra; Chi, Yonggui Robin


Book ID
118153494
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
479 KB
Volume
15
Category
Article
ISSN
1523-7060

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## Abstract The N‐heterocyclic carbene‐catalyzed conjugate umpolung of differently substituted α,β‐unsaturated aldehydes is described. Coupling of these compounds with a variety of trifluoromethylated ketones results in the selective formation of fluorinated γ‐butyrolactones. Using thiazolium‐deriv