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Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

โœ Scribed by Silvia Corvera; Michael P Czech


Book ID
114323410
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
178 KB
Volume
8
Category
Article
ISSN
0962-8924

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The interaction of CD28 with its counter-receptor, B7, induces a cosignal in T cells required to prevent clonal anergy and to promote antigen-dependent interleukin-2 production. The molecular basis of the CD28 cosignal is not well understood but involves the activation of protein tyrosine kinase(s)