Direct Synthesis of Tricarbonyl(cyclopentadienyl)rhenium and Tricarbonyl(cyclopentadienyl)technetium Units from Ferrocenyl Moieties − Preparation of 17α-Ethynylestradiol Derivatives Bearing a Tricarbonyl(cyclopentadienyl)technetium Group
✍ Scribed by Stéphane Masi; Siden Top; Leila Boubekeur; Gérard Jaouen; Stefan Mundwiler; Bernhard Spingler; Roger Alberto
- Book ID
- 102165334
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 136 KB
- Volume
- 2004
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
Abstract
The preparation of new tricarbonyl(cyclopentadienyl)rhenium and tricarbonyl(cyclopentadienyl)technetium derivatives is described. The approach used was applied to a cold target model, 17α‐ethynylestradiol substituted at the 17α position by a ketotricarbonyl(cyclopentadienyl)rhenium group. The novel organometallic reaction applied here, when extended to potential radiopharmaceuticals, consists of a cyclopentadienyl‐ligand transfer between ketoferrocenes and fac‐[^99m^Tc(H~2~O)~3~(CO)~3~]^+^ in a water/DMSO 1:1 mixture. This reaction lead to the synthesis of a new estradiol derivative, labeled with ^99m^Tc. The synthesis of another product was performed by using [^99^TcCl~3~(CO)~3~]^2−^ as the Tc precursor and its X‐ray crystal structure was determined. In each case high yields were obtained. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)