Direct synthesis of nitriles from aldehydes using tetrabutylammonium tribromide in aqueous ammonia
β Scribed by Yi-Zhong Zhu; Chun Cai
- Book ID
- 106214469
- Publisher
- Springer Vienna
- Year
- 2010
- Tongue
- English
- Weight
- 198 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0026-9247
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π SIMILAR VOLUMES
Treatment of aromatic, heterocyclic, aliphatic, conjugated, and polyhydroxy aldehydes with iodine in ammonia water at room temperature for a short period gave the corresponding nitriles in high yields.
A simple and mild method for the conversion of varieties of aldehydes to the corresponding nitriles using aqueous ammonia and aqueous sodium dichloroiodate reagent at room temperature is discussed. Advantages of this system are short reaction time, easy work-up and moderate to good yields.
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