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Direct Synthesis of Heterobiaryls by Radical Addition to Pyridine: Expeditious Synthesis of Chelating Ligands.

โœ Scribed by David Crich; Mitesh Patel


Book ID
101973636
Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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This paper describes the ยฎrst total synthesis of toddaquinoline, an alkaloid from the root bark of Formosan Toddalia asiatica. Importantly, the synthesis has exposed a dichotomy in radical reactions mediated by tin and cobalt(I) that involve additions to pyridines. Our observations suggest that coba