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Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

✍ Scribed by Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi


Book ID
121810176
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
288 KB
Volume
19
Category
Article
ISSN
0947-6539

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Direct Preparation of Trifluoromethyl Ke
✍ JΓΌrgen Wiedemann; Thomas Heiner; Gregorz Mloston; G. K. Surya Prakash; George A. πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 72 KB πŸ‘ 1 views

Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane