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Direct resolution of racemic compounds on chiral microbore columns by sub- and supercritical fluid chromatography

✍ Scribed by Gasparrini, Francesco ;Misiti, Domenico ;Villani, Claudio

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
236 KB
Volume
13
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

Fast resolutions of racemic compounds (sulfoxides, amino alcohols, and α‐methylarylacetic acids derivatives) were achieved on a chiral microbore column using carbon dioxide and a polar methanol/dioxane modifier. The stationary phase used in this study contains the 3,5‐dinitrobenzoyl derivative of R,R(−)‐1,2‐diaminocyclohexane (DACH‐DNB) as the chiral moiety, anchored to a silica gel surface by covalent bonds. Both thermodynamic and kinetic separation performances were improved by using a super‐ or subcritical carbon dioxide mobile phase (SFC, SubFC).

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