Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens

✍ Scribed by Jana Olšovská; Miroslav Flieger; Fiorella Bachechi; Antonella Messina; Massimo Sinibaldi

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 282 KB
• Volume: 11
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/(sici)1520-636x(1999)11:4<291::aid-chir6>3.0.co;2-4

✦ Synopsis

The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.