Direct potentiometric membrane electrode measurements of heparin binding to macromolecules
โ Scribed by Jong Hoon Yun; Shu-Ching Ma; Bin Fu; Victor C. Yang; Mark E. Meyerhoff
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 590 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1040-0397
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A polycation-sensitive membrane electrode based on the ion-exchanger dinonylnaphthalene sulfonate has previously been developed and used as an endpoint detector for the determination of unfractionated heparin in whole blood samples via simple potentiometric titration with protamine. Herein, we repor
A new technique is introduced to study the binding of drugs to macromolecules. The method utilizes rotatingdisk polarography in which a semipermeable membrane covers the surface of the electrode. The membrane permits passage of an electroactive drug but restricts permeability of the macromolecule an