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Direct Palladium-Catalyzed C-2 and C-3 Arylation of Indoles: A Mechanistic Rationale for Regioselectivity

โœ Scribed by Lane, Benjamin S.; Brown, Meghann A.; Sames, Dalibor


Book ID
115481721
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
256 KB
Volume
127
Category
Article
ISSN
0002-7863

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Direct Palladium-Catalyzed C-2 and C-3 A
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We have recently developed palladium-catalyzed methods for direct arylation of indoles (and other azoles) wherein high C-2 selectivity was observed for both free (NH)-indole and (NR)-indole. To provide a rationale for the observed selectivity ("nonelectrophilic" regioselectivity), mechanistic studie

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