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Direct or Indirect Regulation of Calcium-Activated Chloride Channel by Calcium

✍ Scribed by Yafei Chen; Hailong An; Ting Li; Yani Liu; Chongsen Gao; Peng Guo; Hailin Zhang; Yong Zhan

Publisher
Springer
Year
2011
Tongue
English
Weight
707 KB
Volume
240
Category
Article
ISSN
0022-2631

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## Abstract By using pharmacological and molecular approaches, we previously showed that the G‐protein‐coupled, extracellular calcium (Ca)‐sensing receptor (CaR) regulates a large‐conductance (∼140 pS), Ca^2+^‐activated K^+^ channel [I~K(Ca)~; CAKC] in U87 astrocytoma cells. Here we show that eleva