To investigate mechanisms of follicle cell control on mammalian oocyte growth, preantral mouse oocytes free from surrounding follicle cells were individually cocultured with monolayers of different somatic cells competent to form gap junctions, and the rate of in vitro oocyte growth was directly cor
Direct observation of mammalian cell growth and size regulation
β Scribed by Son, Sungmin; Tzur, Amit; Weng, Yaochung; Jorgensen, Paul; Kim, Jisoo; Kirschner, Marc W; Manalis, Scott R
- Book ID
- 115454736
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 397 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1552-4450
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## Background Conlon and Raff propose that mammalian cells grow linearly during the division cycle. According to Conlon and Raff, cells growing linearly do not need a size checkpoint to maintain a constant distribution of cell sizes. If there is no cell-size-control system, then exponential growth