Direct Observation of Catch-Bonds in Focal Adhesions of Living Cells
β Scribed by Bonakdar, Navid; Schilling, Achim; Metzner, Claus; Fabry, Ben
- Book ID
- 119209289
- Publisher
- Biophysical Society
- Year
- 2012
- Tongue
- English
- Weight
- 38 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0006-3495
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The formation of focal adhesions that mediate alterations of cell shape and movement is controlled by a mechanochemical mechanism in which cytoskeletal tensional forces drive changes in molecular assembly; however, little is known about the molecular biophysical basis of this response.
## Abstract Force generated in contractile actin filament bundles (stress fibersβSFs) is transmitted to the extracellular matrix (ECM) via linker proteins and transmembrane integrins at focal adhesions (FAs). Though it has long been known that actin is rapidly exchanged in FAs, the connection betwe