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Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

✍ Scribed by Zarbl, Helmut; Sukumar, Saraswati; Arthur, Anne V.; Martin-Zanca, Dionisio; Barbacid, Mariano

Book ID
109739174
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
963 KB
Volume
315
Category
Article
ISSN
0028-0836

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Mutational activation of c-Ha-ras genes
Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands
✍ Hirotsuka Sakai; Katsuhiro Ogawa πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 665 KB

## Abstract Although administration of a single dose of __N__‐nitroso‐__N__ methylurea (NMU) to young virgin rats induces a high rate of mammary carcinomas, precise histogenesis of the carcinomas has not been well characterized. In this study, we investigated the alterations of H‐__ras__ gene in ea