Direct Monitoring of Organic Reactions on Polymeric Supports

✍ Scribed by Michael R. Carrasco; Michael C. Fitzgerald; Yoshiya Oda; Stephen B.H. Kent

• Book ID: 104257798
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 629 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01456-1

✦ Synopsis

A methodto usc matrix-assistedlaser desorptiotiiorrizationmass spectrome~(MALDI-MS) forrcal-time morntoringoforganicreaetionsonpolymeric suppmtsused insolid-phsse synthesis is described.The stmtegyutilizesa syntheticcotrstrnctthat allowsfortk rapidml convenientdirect MALDIanalysisof the attackd substmtesas well astheirsubs.equcntchcrnicalcleavageas desired.We haveused this strategyto morritornuckophilicsubstitutions,pallsdimrkcatalyzedeouplirtgrcaetiona, and solidphasepcptidesyrttksis rcactioms usingboth Boc-andFmoc-basedchemistries. @ 1997Elsevier Science Ltd.