We wished to test the hypothesis that the non proline cis to trans isomerization of the peptide bond at position 167 in the S. aureus โค-lactamase PC1 exerts a significant controlling effect on the folding pathway of this enzyme. The previous data presented in support of this hypothesis could not rul
โฆ LIBER โฆ
Direct Measurement Indicates a Slow Cis/Trans Isomerization at the Secondary Amide Peptide Bond of Glycylglycine
โ Scribed by Schiene-Fischer, Cordelia; Fischer, Gunter
- Book ID
- 120341391
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 66 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0002-7863
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The cyclic hexapeptide cycle[ -Pro'-Gly2-Glu3 (OBzl) -Pro4-Phe5-Leu6-] ( 1 ; OBzl: benzyl ester) was modeled and synthesized to be used as a chiral site for the separation of enantiomers. Total correlation spectroscopy and nuclear Ovehauser effect spectroscopy spectra of the peptide in CDCIB showed