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Direct Interaction Of A Small Molecule Modulator With G551D-CFTR, A Cystic Fibrosis Causing Mutation Associated With Severe Disease

✍ Scribed by Pasyk, Stan; Li, Canhui; Ramjeesingh, Mohabir; Bear, Christine E.


Book ID
119205392
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
38 KB
Volume
96
Category
Article
ISSN
0006-3495

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Cystic fibrosis (CF) is characterised as a single-gene disorder with a simple, autosomal recessive mode of inheritance. However, translation of CFTR genotype into CF phenotype is influenced by nucleotide sequence variations at multiple genetic loci, and individuals heterozygous for CFTR mutations ar