Direct Inhibition of the Expression of Cyclin D1 Gene by Sodium Butyrate
✍ Scribed by François Lallemand; Delphine Courilleau; Michèle Sabbah; Gérard Redeuilh; Jan Mester
- Book ID
- 115579429
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 356 KB
- Volume
- 229
- Category
- Article
- ISSN
- 0006-291X
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We have studied the effects of sodium butyrate (NaBu) on the expression of genes transduced by retroviral vectors and stably expressed in two salivary gland-derived cell lines, A5-DAP and A5-BAG, established earlier. These cell lines were obtained by infecting A5 cells with the retroviral vectors DA
## Abstract Cyclin D1 is a well‐known cell cycle regulator. Recently, its pro‐survival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated