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Direct in vivo protein transduction into a specific restricted brain area in rats

✍ Scribed by Kyoko Owada-Makabe; Yuji Tsubota; Kazunori Yukawa; Nobuyuki Kakimoto; Xiang-Miang Liang; Masakazu Ichinose; Masanobu Maeda

Book ID
116767441
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
200 KB
Volume
378
Category
Article
ISSN
0304-3940

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Delivery of therapeutic proteins into tissues and across the blood-brain barrier is severely limited by the size and biochemical properties of the proteins. Here it is shown that intraperitoneal injection of the 120-kilodalton Ξ²-galactosidase protein, fused to the protein transduction domain from th