✦ LIBER ✦

Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla

✍ Scribed by Melissa Terpstra; Kamil Ugurbil; Rolf Gruetter

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 181 KB
Volume: 47
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.10146

No coin nor oath required. For personal study only.

✦ Synopsis

Spectral editing of the GABA spin system is hampered by coediting of macromolecule (MM) coherences. To reduce contamination arising from MMs in spectra edited for GABA, the highest field strength currently available for human experimentation (7 Tesla) and MEGA-based editing were used. Despite judicious choice of experimental parameters, MM contamination was found to arise from field drifts. When the MM contribution was accounted for, [GABA] = 0.75 +/- 0.14 micromol/g (mean +/- SD, N = 16) relative to 8 micromol/g creatine (Cr), whereas without accounting for the MM signal [GABA*] = 0.88 +/- 0.23 micromol/g (mean +/- SD, N = 16). Incorporating the direct experimental assessment of MM contamination to the edited GABA signal substantially reduced the variance of the measurement, resulting in concentrations that were in excellent agreement with previous (13)C labeling experiments.

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