Direct furan formation by treatment of alkynyl ketones with strong potassium bases

✍ Scribed by David I. MaGee; James D. Leach; Santosa Setiadji

• Book ID: 104209262
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 517 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00063-0

✦ Synopsis

The reaction of keto-alkynes with strong potassium bases such as KOtBu, KHMDS or KI-I yields substituted furans in moderate to good yields without any special activation of the alkyne required. The method offers both a flexibility and rapid method for the synthesis of di-tri-or tetra-substituted furans, although some yields are only modest at best.