๐”– Bobbio Scriptorium
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Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome

โœ Scribed by Shogo Tokuyama; Hiroyuki Wakabayashi; Ing K. Ho


Book ID
115890625
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
631 KB
Volume
295
Category
Article
ISSN
0014-2999

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Methylxanthines produce a quasi-morphine withdrawal syndrome (QMWS) in opiate naive rats. Additionally, methylxanthine-induced suppression of conditioned behavior in rats is reversed by the alpha2 adrenergic agonist clonidine which also attenuates true opiate withdrawal and the QMWS. Therefore, the