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Direct evaluation of antigen binding to human T lymphocyte clones: involvement of major histocompatibility complex products in antigen binding

โœ Scribed by Edward D. Zanders; Marc Feldmann; Nicola Green; Jonathan R. Lamb


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
541 KB
Volume
14
Category
Article
ISSN
0014-2980

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Residues critical for establishing a trimolecular interaction with a major histocompatibility complex (MHC)-encoded receptor and a T cell antigen receptor (TcR) were determined for an antigenic nonapeptide. The N-terminal residue proved to be involved in binding of the peptide to both receptors and