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Direct, efficient and selective tritiations of paclitaxel and photoaffinity taxoids

✍ Scribed by Arthur Y.L Shu; J.Richard Heys

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 91 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01652-x

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✦ Synopsis

Radiolabeled paclitaxel and three photophore-bearing derivatives were prepared by organoiridiummediated direct tritium exchange under both catalytic and stoichiometric conditions. The resulting tritiated taxoids had specific activities ranging from 53 to 195 Ci/mmol.

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