𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Direct determination of niacinamide in multivitamin preparations

✍ Scribed by O. Pelletier; T. A. Campbell

Publisher
John Wiley and Sons
Year
1961
Tongue
English
Weight
290 KB
Volume
50
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

A simple method for the direct determination of niacinamide in pharmaceutical preparations is described. T h e method involves the reaction of niacinamide in potassium dihydrogen phosphate with cyanogen bromide and barbituric acid. The resulting purple color has a maximum absorbance at 5 5 0 mp. Niacin does not interfere in the reaction unless present at about three times the concentration of that of the amide. The method is accurate and reproducible. Results on multivitamin preparations compare favorably with those by the A.O.A.C. procedure and recoveries of added niacinamide are quantitative.

πŸ“œ SIMILAR VOLUMES

Determination of niacinamide in pharmace
Determination of niacinamide in pharmaceutical preparations
✍ Marshall T. Jeffus; Charles T. Kenner πŸ“‚ Article πŸ“… 1969 πŸ› John Wiley and Sons 🌐 English βš– 449 KB πŸ‘ 1 views

One sample of phenobarbital was eluted quantitatively from the adsorbent with diethyl ether containing 2 z ethanol as a preservative. Prior experimental data showed that diphenylhydantoin was not eluted from the adsorbent with diethyl ether. Preparations containing sodium salts of phenobarbital and/