Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane
Direct Conversion of Primary and Secondary Carboxylic Acids to Trifluoromethyl Ketones.
β Scribed by Jonathan T. Reeves; Fabrice Gallou; Jinhua J. Song; Zhulin Tan; Heewon Lee; Nathan K. Yee; Chris H. Senanayake
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 24 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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A new method for the direct conversion of carboxylic acids to aldehydes using N,Ndimethylchloromethyleniminium chloride and lithium tri-t-butoxyalwninw hydride was established. This method provides a convenient way for the chemoselective reduction of carboxylic acids even with such a functional grou
## Abstract The combined use of high concentration conditions, auxiliary bases, and new catalysts allows for the rapid synthesis of sterically hindered carboxylic acid esters at room temperature. Mechanistic analysis indicates the intermediate formation of acid anhydrides and subsequent rateβlimiti