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Direct Catalytic Asymmetric Three-Component Kabachnik–Fields Reaction

✍ Scribed by Xu Cheng; Richard Goddard; Gernot Buth; Benjamin List

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 313 KB
Volume: 47
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200801173

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✦ Synopsis

The reaction of a carbonyl compound, an amine, and a phosphite by in situ imine hydrophosphonylation [Eq. ( 1)], often called the Kabachnik-Fields reaction, is an attractive approach to a-amino phosphonates.

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