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Direct Calculation of the Information Matrix via the EM Algorithm

โœ Scribed by David Oakes


Book ID
125790623
Publisher
Blackwell Publishing
Year
1999
Tongue
English
Weight
367 KB
Volume
61
Category
Article
ISSN
0952-8385

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## Abstract In linkage analysis, estimated recombination fractions between a disease gene and several markers are used to assign the disease gene to a a particular chromosome region. For rare diseases, locus heterogeneity leads to different recombination fractions in different families, and a set o