✦ LIBER ✦

Direct C-3 lithiation of 1-(triisopropylsilyl)indole

✍ Scribed by Mai Matsuzono; Tsutomu Fukuda; Masatomo Iwao

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 56 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01656-2

No coin nor oath required. For personal study only.

✦ Synopsis

1-(Triisopropylsilyl)indole can be directly lithiated at 3-position with tert-BuLi-TMEDA in hexane at 0°C for 3 h. The generated lithio species is reacted with a variety of electrophiles to give 3-substituted 1-(triisopropylsilyl)indoles in good yields.

📜 SIMILAR VOLUMES

ChemInform Abstract: Direct C-3 Lithiati

ChemInform Abstract: Direct C-3 Lithiation of 1-(Triisopropylsilyl)indole.

✍ Mai Matsuzono; Tsutomu Fukuda; Masatomo Iwao 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Synthesis of 3,4,5-Trisubstituted Indole

Synthesis of 3,4,5-Trisubstituted Indoles via Iterative Directed Lithiation of 1-(Triisopropylsilyl)gramines.

✍ Tsutomu Fukuda; Hiroko Akashima; Masatomo Iwao 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

ChemInform Abstract: Directed C-7 Lithia

ChemInform Abstract: Directed C-7 Lithiation of 1-(2,2-Diethylbutanoyl)indoles.

✍ Tsutomu Fukuda; Ryoichi Maeda; Masatomo Iwao 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

ChemInform Abstract: Selective C-3 and C

ChemInform Abstract: Selective C-3 and C-2 Lithiation of 1-(2,2-Diethylbutanoyl)indole.

✍ Tsutomu Fukuda; Yuka Mine; Masatomo Iwao 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

A Direct Lithiation Route to 2-Acyl-1-(p

A Direct Lithiation Route to 2-Acyl-1-(phenylsulfonyl)indoles.

✍ Jun Jiang; Gordon W. Gribble 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

3-Nitro-1-(triisopropylsilyl)-1H-pyrrol

3-Nitro-1-(triisopropylsilyl)-1H-pyrrole

✍ Kennedy, Alan R. ;Khalaf, Abedawn I. ;Suckling, Colin J. ;Waigh, Roger D. 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 127 KB

C 13 H 24 N 2 2O 2 Si, and 2,4-dinitropyrrole. In the solid state, the title compound exists as discrete molecules with only weak C-HÁ Á Ánitro hydrogen bonds between them.