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Direct binding of ligandin to uridine 5'-diphosphate glucuronosyltransferase 1A1

✍ Scribed by Emi Akizawa; Kotaro Koiwai; Takahide Hayano; So Maezawa; Toyofumi Matsushita; Osamu Koiwai

Book ID
118087912
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
358 KB
Volume
38
Category
Article
ISSN
1386-6346

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## Abstract Pharmacogenetic research indicates a relationship between a polymorphism in the gene encoding uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and irinotecan inactivation, in that degradation of SN‐38, the active metabolite of irinotecan, correlates inversely with the number of