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Direct Activation and Defibrillation of Cardiac Tissue

โœ Scribed by James P. Keener

Book ID
102610559
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
467 KB
Volume
178
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

It is shown that inhomogeneity due to gap junctional resistance allows an excitable cable to be directly activated or defibrillated by the application of a large amplitude point stimulus of short duration. Multiple-scale analysis is used to derive a model equation describing the response of the excitable medium to stimuli, and this equation is analyzed to give quantitative estimates of the direct stimulus threshold and the defibrillation threshold. These estimates are shown to be in good agreement with exprimental findings.

๐Ÿ“œ SIMILAR VOLUMES

Two Biophysical Mechanisms of Defibrilla
Two Biophysical Mechanisms of Defibrillation of Cardiac Tissue
โœ Alain Pumir; Valentin I. Krinsky ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 450 KB

We have studied the mechanisms whereby a strong electric shock terminates chaotic wave propagation in cardiac tissue (defibrillation). In a generic model of cellular excitable tissue with two variables, we have found two mechanisms: one based on excitation (E), and another based on de-excitation (D)