Diphosphorylation of platelet myosin ex vivo in the initial phase of activation by thrombin
β Scribed by Kazuyuki Itoh; Taeko Hara; Fumiko Yamada; Nobuhiko Shibata
- Book ID
- 119121522
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 418 KB
- Volume
- 1136
- Category
- Article
- ISSN
- 0167-4889
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π SIMILAR VOLUMES
Human prothrombin was acetylated to produce a modified prothrombin that upon activation by platelet-bound prothrombinase generates a form of thrombin that does not activate platelets but retains its amidolytic activity on a chromogenic peptide substrate. If normal prothrombin is used in such an assa
## Abstract ## Objective Thrombosis and thrombocytopenia are features of the antiphospholipid syndrome (APS), suggesting that antiphospholipid antibodies (aPL) may bind platelets, causing activation and aggregation of platelets and thrombosis. The intracellular events involved in aPLβmediated plat