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Diphenylethanediamine (DPEDA) as chiral selector: VII. Efficient HPLC resolution of a series of underivatized diarylcarbinols on a chiral stationary phase based on C5-amide-bonded N-3,5-dinitrobenzoyl-DPEDA

✍ Scribed by Norbert M. Maier; Georg Uray

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 335 KB
Volume: 8
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1996)8:7<490::aid-chir5>3.0.co;2-f

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✦ Synopsis

Fast and efficient baseline separation of asymmetrically substituted diarylmethanols and 1,ldiarylethanols was achieved on an endcapped, amidelinked N-3,Minitrobenzoylated, (R,R)-1,2diphenyl-l,2-ethanediaminederived chiral stationary phase (CSP) . Optimal enantioselectivities on this CSP were obtained using 1% 2-propanol in n-heptane as the mobile phase. Enantiorecognition was found to be governed by n-basicity and the substitution pattern of the aromatic substituents. o 1996 Wiley-Liss, Inc.