Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

Cyclic strain induces reactive oxygen sp

Cyclic strain induces reactive oxygen species production via an endothelial NAD(P)H oxidase

✍ Hidetsugu Matsushita; Kuen-ho Lee; Philip S. Tsao 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

Vascular endothelial cells are constantly subjected to pressure-induced cyclic strain. Reactive oxygen species (ROS) have been implicated in atherosclerosis and vascular remodeling. Recent evidence indicates that a vascular NAD(P)H oxidase may be an important source of ROS in both physiologic and pa