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Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity

โœ Scribed by Petr Busek; Jarmila Stremenova; Lucie Sromova; Marek Hilser; Eva Balaziova; Dalibor Kosek; Jana Trylcova; Hynek Strnad; Evzen Krepela; Aleksi Sedo


Book ID
116308158
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1018 KB
Volume
44
Category
Article
ISSN
1357-2725

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## Abstract Protein C inhibitor (PCI) regulates the anticoagulant protein C pathway and also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion. In the present study, we evaluated the effect of human PCI and its inactive derivatives on tumor growth and metastasis of hum