The development of a galenical formulation for poorly water soluble dichloroplatinum(I1) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+)-1,2-bis(4-fluorophenyI)ethyle- nediamine]dichloroplatinum(II) (rac-4F-PtClz),
✦ LIBER ✦
Dinuclear complexes of platinum having anticancer properties. DNA-binding studies and biological activity of Bis(4,4′-dipyrazolylmethane-N,N′)-bis[dichloroplatinum(II) and related complexes
✍ Scribed by John A. Broomhead; Louis M. Rendina; Lorraine K. Webster
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0162-0134
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## Abstract Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2‐acetylpyridine and malonic acid dihydrazide, __N__′,__N__′^2^‐bis[(1__E__)‐1‐(2‐pyridyl)ethylidene]propa