Genomic organization and chromosomal loc
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Steven C. Clifford; Sally Walsh; Katie Hewson; Elaine K. Green; Astrid Brinke; P
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Article
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1999
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John Wiley and Sons
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English
⚖ 134 KB
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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R