Dimethyldiacetoxy silane as a silylating reagent : A new technique for forming siliconides of corticosteroids

✍ Scribed by R.W. Kelly

• Publisher: Elsevier Science
• Year: 1969
• Tongue: English
• Weight: 403 KB
• Volume: 43
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)99186-6

✦ Synopsis

Dimethyldiacetoxysilane

is a convenient reagent for thermal stabilisation of suitable corticosteroids to give siliconides with good gas chromatographic properties. The conversion to the derivative is high and the simplicity and speed of the procedure allows rapid analysis of corticosteroid mixtures.

The technique is applicable to steroids with the x7a,zr-dihydroxy-zo-oxo side chain, but not to such steroids as corticosterone where siliconide formation is not possible. Steroids with unhindered hydroxyl groups form therrnally stable silyl derivatives with this reagent.