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Dimethyl sulfoxide induces heme oxygenase-1 expression via JNKs and Nrf2 pathways in human umbilical vein endothelial cells

✍ Scribed by Chao Liang; Zhanggang Xue; Jing Cang; Hao Wang; Ping Li


Publisher
Springer
Year
2011
Tongue
English
Weight
354 KB
Volume
355
Category
Article
ISSN
0300-8177

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Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1). However, the underlying mechanisms involved in the effect of OA on HO-1 expression are unclear. In the c