Synthesis and X-ray crystal structure of
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Robert B. Palmer; Niels H. Andersen
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Article
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1996
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Elsevier Science
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English
⚖ 242 KB
We report the synthesis and X-ray crystal structure of 1,4-dihydro-2,6-dimethyl-4-(2'isopropylphenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester (4), an analogue of the 1,4dihydropyridine calcium channel antagonist, nifedipine. Solution state NOE data indicate the presence of both rotameric forms