✦ LIBER ✦

Dimerizer-regulated gene expression

✍ Scribed by Roy Pollock; Tim Clackson

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 170 KB
Volume: 13
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(02)00373-7

No coin nor oath required. For personal study only.

✦ Synopsis

Control of gene expression using small molecules is a powerful research tool and has clinical utility in the context of regulated gene therapy. Use of chemical inducers of dimerization, or dimerizers, for this purpose has several advantages, including tight regulation, modularity to facilitate iterative improvements, and assembly from human proteins to minimize immune responses in clinical applications. Recent developments include the use of the rapamycin-based dimerizer system to regulate the expression of endogenous genes, the generation of new chemical dimerizers based on FK506, dexamethasone and methotrexate, and progress towards the clinical use of adeno-associated virus and adenovirus vectors regulated by rapamycin analogs.

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