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Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

โœ Scribed by Ingvarsen, Signe; Madsen, Daniel H.; Hillig, Thore; Lund, Leif R.; Holmbeck, Kenn; Behrendt, Niels; Engelholm, Lars H.


Book ID
118164998
Publisher
Walter de Gruyter GmbH & Co. KG
Year
2008
Tongue
English
Weight
427 KB
Volume
389
Category
Article
ISSN
1431-6730

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Activation of the precursor of gelatinas
โœ Masato Tokuraku; Hiroshi Sato; Sinya Murakami; Yasunori Okada; Yoh Watanabe; Mot ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 871 KB

We have identified a novel membrane-type matrix metalloproteinase (MT-MMP) expressed on the cell surface and inducing activation of pro-gelatinase A in vitro. In this study, we further examined the possibility that MT-MMP is the activator of pro-gelatinase A in tumors as well as in vitro. Expression