The value of measuring inhibin-A (asA dimer) with human chorionic gonadotrophin (total or the sub-units free a-hCG and free P-hCG separately), alpha-fetoprotein (AFP), and unconjugated oestriol (uE,) was examined to determine the effect on the performance of serum screening for Down's syndrome betwe
Dimeric Inhibin A as a Fourth Marker for Down's Syndrome Maternal Serum Screening in Native Japanese Women
β Scribed by Dr. Koyo Yoshida; Yoshinori Kuwabara; Tadao Tanaka; Takekazu Onda; Ryuichi Kudo; Hiroyuki Yamamoto; Akira Sato; Kaoru Yanagida; Takashi Okai; Masato Sakai; Yasushi Takai; Hiraku Uemura; Kazuhiko Hoshi; Yukihito Fukada; Toshihiro Aono; Kazuhisa Maeda; Sachio Ogita; Osamu Ishiko; Yuji Murata; Toru Kanzaki; Faye Myrick; Robert E. Grier
- Book ID
- 109006179
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 344 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1341-8076
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Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We meas
To assess the value of inhibin A as an additional second-trimester maternal serum marker of Down's syndrome we studied 56 affected and 280 unaffected pregnancies matched for gestational age. The median level in the cases was 1.62 multiples of the gestation-specific median (MOM) in the controls, with
A nested case-control study using stored serum samples collected as part of a prospective study of the outcome of pregnancy was performed to investigate concentrations of (dimeric) inhibin-A in maternal serum between 15 and 22 weeks of pregnancy in 200 twin pregnancies and 600 singleton control preg