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Diltiazem and nifedipine reduce thein vitrocontracture response to halothane in malignant hyperthermia-susceptible muscle

✍ Scribed by Pascal J. Adnet; Renee M. Krivosic-Horber; Ghislain Haudecoeur; Hugo G. Reyford; Monique M. Adamantidis; Bernard A. Dupuis

Publisher
Springer-Verlag
Year
1990
Tongue
French
Weight
302 KB
Volume
37
Category
Article
ISSN
1496-8975

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In swine, a point mutation in the ryanodine receptor gene can account for all cases of malignant hyperthermia (MH). The frequency of a corresponding mutation in humans (C1840-T) and its relationship to the in vitro contracture profile is unknown. We screened 192 patients from 28 unrelated northern G