Diketopiperazine Alkaloids from Penicillium spp. HS-3, an Endophytic Fungus in Huperzia serrata

✍ Scribed by Wei-Guang Shan; You-Min Ying; Hai-Ning Yu; Wen-Hong Liu; Zha-Jun Zhan

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 157 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900331

✦ Synopsis

Abstract

Cultivation of the fungus Penicillium spp. HS‐3, an endophytic fungus from the stems of Huperzia serrata, led to the isolation of a new diketopiperazine alkaloid, named as tryhistatin (1), together with three known ones, 2–4, all of which share a similar backbone. The structure of 1 was established by detailed interpretation of the 1D‐ and 2D‐NMR spectra, and HR‐ESI‐MS data. Furthermore, 1D‐ and 2D‐NMR experiments were employed to elucidate the structure of 2 which was deduced previously only on the basis of the LC/MS method. In this article, we confirmed the correctness of the previously reported structure and made a complete assignment of the NMR signals of 2 for the first time.