Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity

Increased risk of grade IV neutropenia a

Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation

✍ André B.P. Van Kuilenburg; Rutger Meinsma; Lida Zoetekouw; Albert H. Van Gennip 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU), and it is suggested that patients with a partial deficiency of this enzyme are at risk of developing severe 5-FU-associated toxicity. We evaluated the importance of DPD deficienc