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Difurocoumarins: Psoralen analogs as photochemotherapeutic agents

✍ Scribed by A. Chilin; P. Manzini; S. Caffieri; P. Rodighiero; A. Guiotto

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
53 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

New tetracyclic psoralen‐like compounds have been synthesized, which are characterized by two furan rings angularly condensed on the coumarin nucleus and are therefore called difurocoumarins. This structural feature may favour the intercalation into the DNA helix and then monofunctionally photoreaction with DNA bases. Their synthesis started from 5,7‐dihydroxy‐4‐methylcoumarin, which was condensed with α‐halo‐ketones; the resulting ketoethers were then cyclized to give the title compounds.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Difurocoumarins: Ps
ChemInform Abstract: Difurocoumarins: Psoralen Analogues as Photochemotherapeutic Agents.
✍ A. Chilin; P. Manzini; S. Caffieri; P. Rodighiero; A. Guiotto πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

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