𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Diffusional release of a solute from a spherical reservoir into a finite external volume

✍ Scribed by Mohammad Jafar Abdekhodaie

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
119 KB
Volume
91
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

An exact solution has been obtained for the release kinetics of a solute from a spherical reservoir with the burst effect initial condition into a finite external volume. The exact solution is derived based on the time Laplace transform method. The results presented here indicate that as the external fluid volume increases, the cumulative release at any time and the releasable amount of the solute at infinite time increase. In addition, for a given external volume, as the polymeric coat thickness increases the fractional release at any time decreases. Experimentally, cumulative release profiles of theophylline microspheres coated with ethylene vinyl acetate copolymer into different external volumes agreed with the mathematical predictions.

πŸ“œ SIMILAR VOLUMES

Adaptive Finite-Element Solution of the
Adaptive Finite-Element Solution of the Nonlinear Poisson–Boltzmann Equation: A Charged Spherical Particle at Various Distances from a Charged Cylindrical Pore in a Charged Planar Surface
✍ W.Richard Bowen; Adel O. Sharif πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 282 KB

A Galerkin finite-element approach combined with an error estimator and automatic mesh refinement has been used to provide a flexible numerical solution of the Poisson-Boltzmann equation. A Newton sequence technique was used to solve the nonlinear equations arising from the finite-element discretiza