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Diffusion tensor imaging of native and degenerated human articular cartilage

✍ Scribed by Xiang Deng; Michelle Farley; Miika T. Nieminen; Martha Gray; Deborah Burstein

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
281 KB
Volume
25
Category
Article
ISSN
0730-725X

No coin nor oath required. For personal study only.

✦ Synopsis

Diffusion tensor imaging (DTI) is potentially sensitive to collagen degeneration in cartilage. In this study, DTI was measured on human cartilage samples with interventions of trypsin and collagenase. The measured preferred diffusion direction was consistent with the zonal structure of collagen network. The glycosaminoglycan concentration decreased and apparent diffusion coefficient increased with both interventions. The fractional anisotropy (FA) was not affected by trypsin and showed a slight increase with combined trypsin and collagenase intervention. DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here.

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