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Diffusion imaging of experimental allergic encephalomyelitis

✍ Scribed by A. C. Heide; T. L. Richards; E. C. Alvord Jr.; J. Peterson; L. M. Rose

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
823 KB
Volume
29
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Diffusion‐weighted magnetic resonance imaging (MRI) was compared with T~2~‐weighted MRI in longitudinal studies of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, in five monkeys (Macaca fascicularis). In a region of the brain that had highly directional myelinated fibers (internal capsule) sequential changes were identified on diffusion‐weighted images on and before the day these changes were detected on conventional T~2~‐weighted images. Changes were also identified on diffusion‐weighted images in brain areas that did not develop T~2~‐weighted abnormalities. This result suggests that diffusion‐weighted image intensities are sensitive to pathologic conditions of the brain that can not be seen on T~2~‐weighted images.

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## Abstract Clinical signs of EAE were infrequently observed (1/20) in adult Hartley guinea pigs challenged with isolated human myelin lipophilin in complete Freund's adjuvant. However, CNS vasculitis and parenchymal infiltration by inflammatory cells were found in 10 of 20 inoculated animals. Loca